Betahistine EP Impurity C

Betahistine EP Impurity C - Names and Identifiers

Name	N-Methyl-N,N-bis(2-pyridylethyl)amine
Synonyms	NSC19005 NSC 19005 Betahistine EP Impurity C Methylbis(2-pyridylethyl)aMine METHYLBIS(2-PYRIDYLETHYL)AMINE N-METHYLBIS[2-(2-PYRIDYLETHYL)]AMINE N-Methylbis[2-(2-pyridylethyl)]aMine N-Methyl-N,N-bis(2-pyridylethyl)aMine N-Methyl-N,N-bis(2-pyridylethyl)amine N-Methyl-N-[2-(2-pyridinyl)ethyl]-2-pyridineethanaMine N-METHYL-N-[2-(2-PYRIDINYL)ETHYL]-2-PYRIDINEETHANAMINE N-methyl-2-(pyridin-2-yl)-N-(2-(pyridin-2-yl)ethyl)ethanamine
CAS	5452-87-9

Betahistine EP Impurity C - Physico-chemical Properties

Molecular Formula	C15H19N3
Molar Mass	241.33
Density	1.067±0.06 g/cm3(Predicted)
Boling Point	126-127 °C(Press: 0.08 Torr)
Solubility	Chloroform (Slightly), Dichloromethane (Slightly), Ethanol (Slightly), Ethyl Ace
Appearance	Form Solid, color Pale Yellow to Light Yellow Oil to Sticky
Color	Pale Yellow to Light Yellow Oil to Sticky
pKa	8.17±0.50(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Physical and Chemical Properties	The bioactive Betahistine EP Impurity C (NSC19005) is a Betahistine impurity. Betahistine is an orally potent histamine H1 receptor agonist and H3 receptor antagonist used in the study of rheumatoid arthritis (RA).
In vitro study	Betahistine (0-10 μM) inhibits [ 125 I]iodoproxyfan binding to membranes of CHO (rH 3(445) R) and CHO (hH 3(445) R) cells with IC 50 values of 1.9 μM and 3.3 μM, respectively. Lead to K i values of 1.4 μM and 2.5 μM, respectively.

Betahistine EP Impurity C - Upstream Downstream Industry

Raw Materials

2-Pyridineethanamine, N-[2-(2-pyridinyl)ethyl]-
Betahistine dihydrochloride
Betahistine
Methylamine
Formaldehyde
2-Vinylpyridine

Betahistine EP Impurity C - Preparation solution concentration reference

	1mg	5mg	10mg
1 mM	4.144 ml	20.719 ml	41.437 ml
5 mM	0.829 ml	4.144 ml	8.287 ml
10 mM	0.414 ml	2.072 ml	4.144 ml
5 mM	0.083 ml	0.414 ml	0.829 ml

Last Update：2024-01-02 23:10:35

Betahistine EP Impurity C - Nature

Solubility

Chloroform (Slightly), Dichloromethane (Slightly), Ethanol (Slightly), Ethyl Ace

Last Update：2024-04-10 22:29:15

Betahistine EP Impurity C - Introduction

N-Methyl-N,N-bis(2-pyridylethyl)amine, also known as DMPEA, is an organic compound. The following is an introduction to its nature, use, formulation and safety information:

Nature:
N-Methyl-N,N-bis(2-pyridylethyl)amine is a colorless to pale yellow liquid with a pungent odor. It is flammable and insoluble in water, but can be dissolved in many organic solvents. It is a weakly alkaline compound.

Use:
N-Methyl-N,N-bis(2-pyridylethyl)amine is often used as a base catalyst in organic synthesis reactions, especially in hydrogenation reactions and amide synthesis. It can also act as an accelerator and solvent for photochemical reactions.

Preparation Method:
N-Methyl-N,N-bis(2-pyridylethyl)amine can be prepared by reacting dioxanamide with methylacetamide in the presence of a base.

Safety Information:
N-Methyl-N,N-bis(2-pyridylethyl)amine is irritating and avoid contact with skin and eyes. When in use, need to wear protective glasses and gloves. Avoid inhaling its vapors and operate in a well-ventilated place. When stored and transported, it should be placed in a sealed container, away from fire and oxidizing agents. In case of misuse or skin contact, seek medical advice or rinse immediately.

Last Update：2024-04-09 01:59:56

Betahistine EP Impurity C - In vitro study

Betahistine (0-10 μM) inhibits [ 125 I ]iodoproxyfan binding to membranes of CHO (rH 3(445) R) and CHO (hH 3(445) R) cells with IC 50 values of 1.9 μM and 3.3 μM, respectively. Lead to K I values of 1.4 μM and 2.5 μM, respectively.

Last Update：2024-04-09 20:52:54